SOD1 and Hyperglycemia: The study done by Giacco et al. (2010) suggested that hyperglycemia increased the advanced glycation end products (AGE), facilitated the production of free radicals, and reactive oxygen species (ROS) which were produced by malfunctioning endogenous scavengers such as superoxide dismutase (SOD) and catalase (Giacco and Brownlee, 2010).