HLA-DRB5 and colorectal carcinoma: ,5 We show here that these prognostic immune response genes are highly coordinately expressed in CRC and correlate with other biologically associated genes including HLA-DQA1, HLA-DRB5, HLA-DPB1, LAG3, TIM3, CTLA4, and CCL5. The degree of correlation between immune checkpoint receptor/ligand gene expression was notable (Table S2).