However, by predicting value of serum soluble ST2 and interleukin-33 are used for risk stratification and prognosis in patients with acute myocardial infarction [36] while circulating biomarkers such as different factors, proteins, ions, stimulators of heart muscles, or deactivators can predict heart failure [37] (Figure 4). The gene discussed is IL1RL1; the disease is heart failure.