In type 1 diabetes, pancreatic β-cell failure is mediated by inflammatory cytokines, including interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ), which may stimulate production of RNS, especially nitric oxide (NO) [8]. This evidence concerns the gene TNF and type 1 diabetes mellitus.