In glioma cells, the up-regulation of MMP-13 by leptin was mediated through p38 MAP kinase and NF-κB pathway [35], while in pancreatic cancer cells, we found that the expression of MMP-13 was regulated through JAK2/STAT3 signaling pathway in response to leptin stimulation. This evidence concerns the gene NFKB1 and pancreatic neoplasm.