Our data underscores the importance of targeting DCLK1 not only in chronic liver diseases and HCC but also tumors of intestine, colon and pancreas where DCLK1 has been shown to be overexpressed [41, 56], In summary, the studies describe a novel feed-forward-like loop of DCLK1 signaling network that appears to control inflammation and neoplastic transformation during chronic liver diseases. The gene discussed is DCLK1; the disease is hepatocellular carcinoma.