Moreover, if it is known that activation pathway of IL-8 and IL-10 through p38-MAPK can be proven to have role in the pathway of NPC therefore this pathways can be used as biologic targeted of therapy in the treatment of NPC in the future (Sunil & Govindarajan, 2005; Meichi et al., 2008). This evidence concerns the gene IL10 and nasopharyngeal carcinoma.