Studies suggest that Vitamin D increase production IL-10, an antiinflammatory cytokine involved in the pathogenesis of asthma, from T cells, increase production IL-37, antimicrobial peptide, regulate matrix metalloproteinases (MMP), shifting theTh1 and Th2 balance and reducing inflammation (Xystrakis et al., 2006, De Smet et al., 2005; Finklea et al., 2011). The gene discussed is IL10; the disease is asthma.