2009). Although the BALB/cNctr‐Npc1m1N/J strain has been the most intensively studied, there are also other authentic mammalian animal models of NPC. Interestingly, loss of Npc1 in mice on the C57BL/6 genetic background results in more acute disease relative to the BALB/cNctr‐Npc1m1N/J mouse (Parra et al. 2011), suggestive of genetic modifiers. A feline model of NPC has also been characterized (Brown et al. 1994) and successfully used to trial experimental therapies (Stein et al. 2012). The gene discussed is NPC1; the disease is nasopharyngeal carcinoma.