Consistent with the potential protective role of Th17 cells againstthe development of allergies are the negative correlation between IgE and Th17 cells inatopic dermatitis (Hayashida et al. 2011) and the report of an impaired Th17 celldifferentiation in autosomal dominant hyper IgE syndrome (Milner et al. 2008). This evidence concerns the gene IGHE and Autosomal dominant hyper-IgE syndrome.