In lung cancer tissues, TIPE2 showed strong staining in primary lung adenocarcinoma and lymph node metastasis tissue (Fig 1D, 1E and 1F), but exhibited very weak staining in lung squamous cancer and even almost no staining in most of small cell lung cancer (Fig 1G, 1H and 1I). This evidence concerns the gene TIPE2 and lung adenocarcinoma.