FMO5 and chronic granulomatous disease: Tests with ROS-inhibited control neutrophils and neutrophils from ROS-deficient CGD patients demonstrated that NETosis induction by high UA levels occurs in a NADPH oxidase/ROS-independent manner, with nuclear factor “kappa-light-chain-enhancer” of activated B-cells (NF-κB) playing a role in the signaling pathway [136].