Here we report that Abl kinases link Met receptor activation to RhoA signaling leading to actomyosin contractility in epithelial cells, and demonstrate that inhibition of Abl kinases suppresses HGF-induced cytoskeletal remodeling processes required for cell scattering and tubulogenesis of non-transformed Madin Darby canine kidney (MDCK) epithelial cells, as well as migration and invasion of breast cancer cells. The gene discussed is HGF; the disease is breast carcinoma.