H6PD and renal cell carcinoma: Taken together, these findings in association with high levels of PPP enzymes (G6PDH and TKT) and metabolic intermediates (sedoheptulose 7-phosphate, ribose 5-phosphate, and ribulose 5-phosphate/xylulose 5-phosphate), suggest that a rerouting of the sugar metabolism toward the PPP occurs, with the aim of promoting both anabolic reactions and redox homeostasis in RCC.