PKM and renal cell carcinoma: Analysis of the glycolytic enzymes Glucose-6-phosphate isomerase/Autocrine motility factor (G6PI/AMF), L-lactate dehydrogenase A chain (LDH-A), Pyruvate kinase isoform M2 (PKM2) and Transketolase (TKT) demonstrated an increased expression of all these proteins in RCC as compared with non neoplastic tissue (Figure 1B and 3).