Analysis of the glycolytic enzymes Glucose-6-phosphate isomerase/Autocrine motility factor (G6PI/AMF), L-lactate dehydrogenase A chain (LDH-A), Pyruvate kinase isoform M2 (PKM2) and Transketolase (TKT) demonstrated an increased expression of all these proteins in RCC as compared with non neoplastic tissue (Figure 1B and 3). The gene discussed is TKT; the disease is renal cell carcinoma.