SPON2 and colorectal carcinoma: Using multivariate Cox regression method, we revealed that SPON2 protein expression (HR = 1.786, 95% CI = 1.249-2.555, p = 0.001) and high N stage (HR = 2.554, 95% CI = 1.655-3.940, p = 0.000) were hazard factor of overall survival of CRC patients (Table 3).