In colon cancer, as an single independent diagnostic or prognostic biomarker, the performance of SPON2 might be equivalent or better than some raised biomarkers, such as carcino-embryonic antigen (CEA) (AUC = 0.856, sensitivity 74%) [35], cancer antigen (CA) 19-9 (AUC = 0.58, sensitivity 26%) [35], dipeptidase 1 (AUC 0.923) [36], interleukin-8 (AUC = 0.742, sensitivity 85.4%/specificity 54%) [37], miR-21 (AUC = 0.867, sensitivity 76%/specificity 82%) [38] and kininogen-1 (AUC = 0.635, sensitivity 70%/specificity 66%) [39]. This evidence concerns the gene DPEP1 and malignant colon neoplasm.