Furthermore, SPON2 was found to be significantly elevated in every types of colon cancers, including colon adenocarcinoma (n = 101, p = 8.2E-6), rectal adenocarcinoma (n = 60, p = 2.1E-6), colon mucinous adenocarcinoma (n = 22, p = 1.5E-7) and cecum adenocarcinoma (n = 22, p = 0.02), as revealed in TCGA Colorectal dataset (Figure 1G). This evidence concerns the gene SPON2 and digestive system cancer.