SPON2 and colorectal carcinoma: By the TMA-IHC assays, we identified in univariate analyses that high T stage (HR = 2.332, 95% CI = 1.267-4.291, p = 0.007), N stage (HR = 2.530, 95% CI = 1.673-3.825, p = 0.000), high grade (HR = 2.470, 95% CI = 1.071-5.695, p = 0.034) and high SPON2 protein expression (HR = 1.860, 95% CI = 1.298-2.665, p = 0.001) were risk factors of overall survival of CRC patients (Table 3).