By univariate analysis using the Smith Colorectal 2 dataset in Oncomine database, we revealed that recurrence (Hazard ratio (HR) = 9.462, 95% confidence interval (CI) = 3.395-26.368, p < 0.001), high SPON2 expression (HR = 3.245, 95% CI = 1.243-8.473, p =0.016) and high level stage (HR = 2.972, 95% CI = 1.562-5.654, p = 0.001) were hazard factors for overall survival of CRC patients (Supplementary Table 1). This evidence concerns the gene SPON2 and colorectal carcinoma.