In line with other studies reporting the cytoprotective role of Trx1 and TrxR1 [17, 47], we showed that both drug-induced inhibition and specific knockdown of Trx1 and TrxR1 reduced MM cell proliferation, induced cell death, and apoptosis (Figures 2 and 4). Here, TXNRD1 is linked to Miyoshi myopathy.