We found 18 SNPs in 14 atopy-related genes (CSF2, DENND1B, DPP10, FLG, IL13, IL13RA2, LRP1B, NOD1, NPSR1, ORMDL3, RORA, STAT4, TLR6, TRA) were significantly associated with pancreas cancer risk. The gene discussed is ORMDL3; the disease is pancreatic neoplasm.