We found 18 SNPs in 14 atopy-related genes (CSF2, DENND1B, DPP10, FLG, IL13, IL13RA2, LRP1B, NOD1, NPSR1, ORMDL3, RORA, STAT4, TLR6, TRA) were significantly associated with pancreas cancer risk. This evidence concerns the gene CSF2 and pancreatic neoplasm.