InSouthern Brazil, a variant form of LFS, Li-Fraumeni-like syndrome (LFL), occurs as aresult of a founder mutation in exon 10 of TP53, replacing an argininewith histidine at codon 337 (p.R337H), which falls within the oligomerization domain(7). The gene discussed is TP53; the disease is Li-fraumeni-like syndrome.