The TP53 p.R337H founder mutation was reported to beassociated with Brazilian families with LFL in 2007 (2), and has an estimated population frequency of 0.3 in Southern andSoutheastern regions of Brazil, where the incidence of adrenocortical carcinoma is 10-to 15-fold greater than in other countries (30,31). This evidence concerns the gene TP53 and adrenal cortex carcinoma.