In a very different approach, high-throughput screening against P. falciparum dihydroorotate dehydro­genase and lead optimization of an active triazolopyrimidine has led to potent selective inhibitors of malaria parasites that are in human testing (Baldwin et al., 2005 ▶; Phillips et al., 2008 ▶; Coteron et al., 2011 ▶; Deng et al., 2014 ▶; Gujjar et al., 2011 ▶; http://www.mmv.org/research-development/rd-portfolio). Here, DHODH is linked to malaria.