Neutrophil serine proteases are implicated in the destruction of tissue in a wide range of diseases such as acute respiratory distress syndrome (ARDS), chronic obstructive lung disease, bronchiectasis, alpha-1 antitrypsin deficiency, cystic fibrosis, granulomatous angiitis, rheumatoid arthritis, and gout[44–51]. The gene discussed is SERPINA1; the disease is rheumatoid arthritis.