Finally, multivariate logistic regression involving simultaneous analysis of all the studied polymorphisms, haplotypes, and gene-gene interactions revealed the following factors to be relevant in susceptibility to ccRCC: CAGT haplotype in VDR (P = 0.005), interaction between rs4765623 in SCARB1 and rs9679290 in EPAS1 (P = 0.007), interaction between variants “r” in MC1R and rs7975232 in VDR (P = 0.010), and interaction between rs7121 in GNAS1 and rs2228570 in VDR (P = 0.041) (Table 4). Here, EPAS1 is linked to nonpapillary renal cell carcinoma.