According to MDR analysis, ccRCC is best explained by the four-factor model comprising rs4765623 in SCARB1, rs4953346 in EPAS1, rs9904341 in BIRC5, and rs7121 in GNAS1 with balanced accuracy (BA) of 0.5828, cross-validation consistency (CVC) of maximum level 10/10, and permutation testing P value of 0.036 (Table 2). The gene discussed is GNAS; the disease is nonpapillary renal cell carcinoma.