A meta-analysis, encompassing 6 studies including 1826 obese individuals and 11 studies including 1570 subjects with T2DM, provides evidence of higher vaspin levels in obesity and T2DM and emphasizes the pivotal role of vaspin in the progression of metabolic and glucose abnormalities and, thus, its promising potential as a cardiovascular risk marker [64]. Here, SERPINA12 is linked to obesity due to melanocortin 4 receptor deficiency.