These data are a prerequisite to believe that probably vaspin is involved in the process of carotid plaque formation in the early stages of diabetes and that increased vaspin production in human adipose tissue in this period may be a compensatory mechanism associated with obesity, severe insulin resistance, and the development of T2DM and, therefore, may serve as a new biomarker and a protective factor for macrovascular lesions [63]. This evidence concerns the gene SERPINA12 and Insulin resistance.