SERPINA12 and metabolic syndrome: In a study, evaluating vaspin levels before and after a 12-week program for weight reduction with orlistat, it has been found that vaspin levels are significantly lower in responders, defined as subjects with ≥2% weight reduction from baseline [23], whereas Kim et al. findings have shown no alteration in vaspin levels after a 10-month program of lifestyle modification in subjects with MetS [44].