In another study Nakatsuka et al. have demonstrated that vaspin serves as a ligand for a cell-surface GRP78/voltage-dependent anion channel complex in endothelial cells as well and, thus, exerts antiapoptotic, proliferative, and protective effects on vascular walls in rat models with streptozotocin-induced diabetes mellitus [11]. This evidence concerns the gene SERPINA12 and diabetes mellitus.