Furthermore, a number of tumor suppressor genes, including hMLM1, p14, p15, GSTP1, RASSF1, COX-2, APC, CDH4, DAP-K, THBS1, TIMP-3, RARβ, MGMT, CHFR, DCC, RUNX3, and TSLC1, are known to be silenced by hypermethylation in gastric cancer [31] (Figure 3). Here, APC is linked to gastric cancer.