LEF1 and focal segmental glomerulosclerosis: Despite that, we do not show regulation of the transcription factor TCF/LEF in our model; the upregulation of LEF-1 and TCF transcription factor has been demonstrated in the UUO rats [33, 34] and the colocalization of β-catenin with the transcription factor LEF-1 in the nuclei of podocytes has been shown in rats with focal glomerulosclerosis [35]; therefore it is conceivable that in 2K1C rats the interaction of β-catenin with TCF/LEF transcription factors could mediate the upregulation of its target genes.