Erythropoietic protoporphyria (EPP) is a hereditary disease due to a decreased activity of ferrochelatase (Fech) (EC.4.99.1.1), the last enzyme of heme pathway catalyzing the incorporation of ferrous iron (II) into protoporphyrin IX (PROTO IX) to synthetize heme [1, 2]. The gene discussed is FECH; the disease is erythropoietic protoporphyria.