Seventeen percent of gastric carcinoma patients in the initial study and 15% of the noncardia gastric carcinoma patients in the replication study had 1 or 2 TLR4 variant alleles versus 8% of both control populations (combined OR = 2.3; 95% CI = 1.6–3.4) [78]. Here, TLR4 is linked to gastric carcinoma.