In a case-control study and meta-analysis, Castaño-Rodríguez and coworkers reported that the TLR signaling pathway was implicated in gastric carcinogenesis, with TLR4 Asp299Gly and TLR2 −196 to −174 del showing associations with gastric cancer in an ethnic-specific manner [79]. This evidence concerns the gene TLR4 and gastric cancer.