As noted above, we found that AC5 KO increases life span and protects against oxidative stress though upregulating the antioxidant, MnSOD [4], whereas MnSOD regulated the cardiomyopathy induced by chronic catecholamine stimulation through the AC5, SIRT1, FoxO3a, and MnSOD pathway [3]. This evidence concerns the gene ADCY5 and cardiomyopathy.