AQP5 and Keratoconjunctivitis sicca: Chrysotoxine isolated from D. nobile can increase the expression of AQP-5 in dry eyes, one of the symptoms of SS, and restore the distribution of AQP-5 in lacrimal glands and corneal epithelia, by inhibiting the release of cytokines, such as IL-1, IL-6, and TNF-α.