A similar mechanism of Fas ligand-independent, FADD-mediated activation of the Fas death pathway was observed in human melanoma cells treated with curcumin [32], human colon and leukemic cell lines treated with cisplatin and etoposide [33, 34], and head and neck squamous carcinoma cells treated with the synthetic retinoid MX3350-1 [35]. This evidence concerns the gene FAS and melanoma.