TP53 and carcinoma: Classical “adenoma-carcinoma” sequence which includes changes from the normal mucosa towards the carcinoma belongs to specific and well defined genetic alterations such as APC (adenomatous polyposis coli), and oncogenes as KRAS (Kristen rat sarcoma viral oncogene homolog), DCC (deleted in CRC), and TP53 (tumor protein 53) [21].