GIMAP5 and type 1 diabetes mellitus: In a spontaneous rat model of type I diabetes (the BioBreeding diabetic prone (BB-DP) rats), abnormal thymocyte development and premature death of peripheral CD4+ and CD8+ T-cells [110, 118, 119] were linked to a frame shift mutation in GIMAP5, designated lyp, causing a truncated nonfunctional protein (GIMAP5lyp/lyp) [100–106].