In a cohort of 200 patients suffering from CKD stages 3 and 4, higher levels of CPPs were associated with hyperphosphatemia, increased levels of C-reactive protein, oxidized low density protein, bone morphogenic proteins 2 and 7 as well as a rapid decline in renal function, and a greater aortic pulse wave velocity ((PWV) beta coefficient 0.059, P = 0.016, R2 = 0.362) which is known to be a strong predictor of major CV events in CKD patients [107]. This evidence concerns the gene CRP and chronic kidney disease.