NPPB and chronic kidney disease: In a prospective evaluation of 213 CKD nondialysis patients, Vickery and coworkers demonstrated that NT-proBNP (≥89 pmol/L, HR 2.5, P < 0.05) and high-sensitivity C-reactive protein (hsCRP ≥ 4.7 mg/L, HR 1.9, P < 0.05) were independently associated with increased all-cause mortality [3].