In the CRIC cohort of 3386 patients suffering from CKD 2–4, NGAL was an independent predictor of worsening of CKD (defined as a 50% eGFR decrease or dialysis initiation) but it did not add significantly to the discrimination model suggesting a marginal value of urinary NGAL as a predictor of CKD progression [134]. Here, LCN2 is linked to chronic kidney disease.