It should be noted that nearly all patients were treated with statins in our study, which might influence the results of the analysis of the association between the studied genetic variant and cholesterol level in CAD group. CYP7A1 gene polymorphisms may also modify response of organism to lipid lowering drugs [25, 26], which may be another reason of the obtained results. The gene discussed is CYP7A1; the disease is coronary artery disorder.