In our study, we provided evidence that MM cell-derived exosomes induced caspase-3 activation in Raw264.7 cells, even in absence of a clear apoptosis; notably, treatment with MM cell-derived exosomes fails to induce TRAP activity in Raw264.7 cells that were pharmacologically inhibited for caspase-3 activity. The gene discussed is CASP3; the disease is Miyoshi myopathy.