IGF1R and non-small cell lung carcinoma: Previous studies also interrogated IGF-1R gene copy number status in a panel of NSCLC cell lines and found cell lines with high IGF-1R copy number were significantly more sensitive to the IGF-1R antibody R1507 compared with those with low IGF-1R copy number [7], suggesting the potential value of IGF-1R gene copy number as a predictive marker for anti-IGF-1R monoclonal antibody.