Acute promyelocytic leukemia (APL) is associated in almost all cases with chromosomal translocation t(15;17)(q24;q21) involving the RARA and PML genes at 17q21 and 15q24, respectively, resulting in the fusion transcript PML-RARA which encodes for the oncoprotein at the basis of the APL pathogenesis [1]. This evidence concerns the gene RARA and acute promyelocytic leukemia.