In human bronchial epithelial cells or lung cancer cells, we had shown that As3+ is able to activate protein kinase Akt through either inducing miR-190 or initiating the signaling cascade from JNK to STAT3 that contributes to Akt-dependent EZH2 phosphorylation, cell transformation and/or migration [7–10]. Here, AKT1 is linked to lung carcinoma.