The functional relationship between CagA and inflammasome is of particular interest in light of the fact that polymorphisms in the IL1B gene, which encodes IL-1β, are associated with increased gastric cancer risk in the context of H. pylori infection53 and the fact that transgenic overexpression of IL-1β in parietal cells induces gastric dysplasia/carcinoma in mice54. This evidence concerns the gene IL1B and carcinoma.