In LNCaP prostate cancer cells, reduced expression of SAM68 altered the expression of an important subset of genes involved in proliferation and apoptosis, including Bcl2L1, Clusterin, cdk2, cdk3, p16INK4, cyclin D1, Par-4, EGF and IGF-1 [21]. The gene discussed is CDKN2A; the disease is Familial prostate cancer.