Analogous to wild-type and E50K optineurin transduced eyes, an enhanced optineurin, reduced PSMB5 and increased LC3 staining was observed in the RGC layer of sections from injury grades 2.75 and 5 compared to injury grade 1.0 (normal) in the rat ocular hypertension model (Figure 5A, left panel). The gene discussed is PSMB5; the disease is ocular hypertension.