Such patients are currently under investigation at CHR, with preliminary evidence suggesting that they represent women with a lean polycystic ovary syndrome (PCOS) – like ovarian phenotype at young ages, at older ages characteristically, however, presenting with severe hypoandrogenemia; yet, as here observed in NYU patients, still surprisingly good FOR (reflected in AMH and oocyte yield) considering their ages (Gleicher N, Kushnir VA, Barad DH, unpublished observations). The gene discussed is AMH; the disease is polycystic ovary syndrome.