These include the carbon degradation genes amyA, nplT-1 (neopullulanase), nplT-2, and exochitinase in the CF samples; the carbon degradation genes amyA, ara-fungi, phenol-oxidase, and mannanase in the MBF samples; and the carbon degradation genes pectinase and amyA, and the carbon fixation genes RuBisCO and CODH in the DBF samples (Supplementary Table S5, Supplementary Fig. S2A). The gene discussed is MANBA; the disease is cystic fibrosis.