We showed that unlike the traditional separate analysis of gene expression profiles (43,44) or the aberration of miRNA expression in cancer tissues (45,46), this integrated molecular analysis of deregulated miRNAs and genes using TFmiR was able to uncover literature confirmed core regulators as well as important new aspects of the TF/gene-miRNA interactomes, their co-regulation mechanisms, and the underlying pathogenesis of human breast cancer. This evidence concerns the gene TF and cancer.