VEGFA and age-related macular degeneration: Age-related macular degeneration (AMD) is the leading cause of severe visual loss in patients over the age of 50 years in Europe and North America.1, 2 Neovascular AMD (nAMD) is characterised by choroidal neovascularisation (CNV), which is the growth of abnormal, choroidal blood vessels beneath the macula, which causes severe loss of vision and is responsible for the majority of visual loss due to AMD.3 One of the key mediators implicated in the pathogenesis of CNV in nAMD is vascular endothelial growth factor-A (VEGF).