VEGFA and age-related macular degeneration: Clinical and economic evidence was initially informed by the Anti-vascular endothelial growth factor Antibody for the Treatment of Predominantly Classic Choroidal Neovascularization in Age-related Macular Degeneration (ANCHOR) and Minimally Classic/Occult Trial of the Anti-VEGF Antibody Ranibizumab in the Treatment of Neovascular Age-Related Macular Degeneration (MARINA) studies, which demonstrated that ranibizumab prevents central vision loss and improves mean visual acuity (VA) at 2 years when given at monthly intervals in eyes with subfoveal nAMD.6, 7