In the study, we found that 1d and 2d postoperative, both the serum level of IL-6 and level of TNF-α in Group P1, P2 and P3 were significantly lower than that in Group C (P < 0.05); and that in Group P2 and P3 were significantly lower that that in Group P1 (P < 0.05) (Table 4), indicating that multi-mode pre-emptive analgesia can effectively suppress postoperative inflammatory reaction in transabdominal hysterectomy, and the combination of analgesia drugs with multi-mode mechanisms by different routes of administration shows better analgesic effect. Here, IL6 is linked to hysterectomy.