AFP and hepatocellular carcinoma: The results indicated that AFP expressed in HBV-infected tissues, HBV positive cirrhosis liver tissues and HBV-related HCC tissues was 42.8%, 70.6% and 86.4% respectively; AFPR expressed in these tissues was 50.0%, 75.5% and 90.9% respectively; Src expressed in these tissues was 28.6%, 52.9% and 63.6% respectively; The levels of AFPR was significantly higher in AFP+/HBV+ liver tissues than in AFP-/HBV+ or AFP-/HBV- liver tissues (Additional file 1).