Gutierrez A Jr et al reported the aberrant protein expression of LEF1 specifically in CLL not normal B cells and they also identified LEF1 expression in CD19(+)/CD5(+) cells obtained from patients with monoclonal B-cell lymphocytosis, suggesting a role for LEF1 early in CLL leukemogenesis [26]. This evidence concerns the gene LEF1 and B-cell chronic lymphocytic leukemia.