A work carried out by Jia and coworkers (2014) showed that Sm29 could be a partner of TSP-2 for generation of protein complexes called tetraspanin-enriched microdomains (TEMs), which seem to be essential to worm survival and are of particular importance for the development of a multivalent vaccine against schistosomiasis [24]. Here, THBS2 is linked to schistosomiasis.