While the vitamin digestion and absorption pathway in the PMS clinical subtype is activated by the increase in the APOA4, APOA1, SCARB1 proteins, it has been observed that the notch signaling pathway is also activated through NOTCH2, EP300, PSEN1, DTX1, JAG2 proteins, which may reflect the fact that the vitamin metabolism of MS is dysregulated and this is supportive with the recently suggested vitamin metabolism involvement in MS pathogenesis [37]. This evidence concerns the gene EP300 and myeloid sarcoma.