Our results are in agreement with previous studies showing that the overexpression of dominant-negative truncated TrkB and BDNF+/– deficiency exacerbates memory declines in the water maze task but has no effect on cerebral Aβ accumulation in APP/PS1 or 3xTg-AD mice.51, 52, 53 Therefore, the investigations using different AD mouse models seem to consistently support the idea that deficient BDNF/TrkB signaling may contribute to the worsening of memory deficits in AD without accelerating β-amyloidosis. This evidence concerns the gene APP and Alzheimer disease.